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  3. Cushing Disease: The Slow, Grumpy Older Dog
Diseases·25 March 2026·5 min read

Cushing Disease: The Slow, Grumpy Older Dog

Drinks gallons, pot belly, hair loss, skin thinning - when "old age" is actually treatable disease.

Cushing Disease: The Slow, Grumpy Older Dog

What it is

Over-production of cortisol (stress hormone), usually from a small benign pituitary tumour. Common in older small breeds (Dachshund, Poodle, Beagle).

Signs

  • Excessive thirst and urination
  • Increased hunger
  • Pot-bellied appearance
  • Hair thinning along trunk; black skin pigmentation
  • Panting at rest
  • Lethargy
  • Recurrent skin/UTI infections

Why it gets missed

Owners attribute symptoms to ageing. By the time we see the dog, signs have been progressing 1-2 years.

Diagnosis

LDDS test, ACTH stimulation, urine cortisol:creatinine ratio, abdominal ultrasound. Multi-step but worthwhile.

Treatment

Daily oral medication (trilostane). Quarterly monitoring bloodwork. Symptoms improve dramatically over 2-3 months.

Prognosis

Well-managed Cushing dogs live their normal lifespan with good quality of life.

Frequently asked

Trilostane has good safety record with monitoring. We track quarterly to keep dose right.

Some mild cases yes. Most progress and reduce quality of life.

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